Cabot’s Ring

Cabot rings are ring-like or figure-of-eight loop-shaped inclusions composed of microtubule remnants from the mitotic spindle, or possibly nuclear remnants or abnormal histones. Can indicate B-12 anemia and related diseases, megaloblastic anemia, myelodysplastic syndrome, and lead poisoning.

https://www.ncbi.nlm.nih.gov/books/NBK594259/

https://haematologyetc.co.uk/index.php?title=Cabot_rings

Occur in states of stressed haematopoiesis:

  • Megaloblastic anaemias
  • Myelodysplasia and myelofibrosis
  • Drug effects
  • Cabot rings are frequently observed in myelodysplastic syndrome, myelofibrosis, chronic myeloid leukemia, and megaloblastic anemia. Megaloblastic anemia is often the result of nutritional deficiencies, including vitamin B12 and folate deficiency. Deficiencies commonly arise from reduced dietary intake, as seen in vegetarian or vegan diets, or impaired absorption. Celiac disease. The use of certain medications, inborn errors of metabolism, pernicious anemia, and many other pathologic processes may result in megaloblastic anemia.
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