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This powerful therapy is commonly chosen by:
As an added bonus, because BSI is a not-for-profit corporation, our prices for NAD+ NMN+ therapies are by far more affordable. BSI is required to reinvest all profits back into the Corporation (not allowed to make a profit) – as such we can offer the highest quality ingredients and therapies, no cutting corners.
NAD+ NMN+ IV Infusion Therapies have been proven to help relieve age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression.
NAD+ NMN+ IV Therapies help restore natural / native NAD levels in your body through several pathways. Your body makes native NAD from native NMN (nicotinamide mononucleotide), by converting it with enzymes called kinases. And when depleated native NAD needs immediate supplementation, NAD+ is also prescribed for fast effect, while NMN+ helps stimulate the body to produce more youthful levels of native NAD over time. Different combinations are prescribed for different goals or problems.
Who Is Electro NAD+ NMN+ Therapy Suitable For?
NAD / Native NAD (Nicotinamide adenine dinucleotide). Native NAD is a coenzyme found in every cell in the body. It balances metabolism and hormonal activity, restores tissue damage, regulates brain function, augments energy, and acts as a natural antidepressant. As we age, native NAD decreases and a key to health aging is keeping this is good supply and balance in the body.
NAD+ (β-Nicotinamide Adenine Dinucleotide), is a supplemental and medicinal derivative of Niacin (Vitamin B3). NAD, NAD+, NMN+, and Niacin are unrelated to nicotine.
NAD+ IV therapy is a healthy alternative to pharmaceutical medications for a variety of recovery or enhancement treatments. The “+” means this is the supplement form of native NAD. NAD without the “+” is what is naturally manufactured in the body, known simply as NAD, or what we call native NAD.
NAD+ stimulates the body to replace and balance depleted vitamins and minerals, and increase natural defenses to detox the body of artificial chemicals so it can heal. It greatly helps to repair and restore the body from damages and stressors, and also helps counter depression and mood-swings.
Most importantly, NAD+ Therapy reduces non-beneficial cravings. Unlike most pharmaceutical treatment options, there are no harmful side effects associated with NAD+ treatment.
NAD+ IV Therapy directly increases NAD+ in the bloodstream. However, it may require frequent administration, because NAD+ heals and is metabolized relatively quickly (more so for older adults who tend to be more depleted in native NAD). This often makes more frequent dosing necessary to maintain elevated NAD levels.
This is where NMN+ comes in….
Native NMN (Nicotinamide mononucleotide). NMN without the “+” is what is naturally manufactured in the body, known simply as NMN, or what we call native NMN.
NMN+ (β-nicotinamide mononucleotide). The “+” means this is the supplement form of native NMN.
NMN+ is a powerful NAD production stimulant and is more bio-available than NAD+ as it can enter cells more easily and directly. Once inside the cells, NMN+ is quickly converted into NAD. NMN+ provides a more sustained elevation of native NAD levels over time, even with less frequent dosing.
NMN+, or β-nicotinamide mononucleotide, is also derived from Niacin (Vitamin B3), and serves to supplement decreased native NMN, which is also naturally produced in the body, just like native NAD. However, its production decreases as we age. As native NMN levels decline, signs of aging, reduced physical ability, and cognitive decline can begin to appear.
Studies, and experience with patients, have shown that NMN+ Therapy can lead to dramatic improvements in both appearance and bodily functions, almost like turning back the clock. This has earned NMN+ the title of a “rejuvenating medicine” and it is gaining worldwide attention.
Foods like broccoli and cucumbers contain NAD and NMN, however the amount required to achieve significant benefits would be impractical through diet alone. For example, to ingest just 1 mg of NMN from broccoli, you’d need to consume about 100 kg of broccoli. NMN+ intravenous (IV) therapy offers a much more efficient method for delivering this powerful compound into the body.
By Dr. Jo, Chief Scientist and Head Doctor with BSI International Clinics at Bali.
(adjuvants increase effectiveness of the other medicines).
NAD+ and / or NMN+ IV Therapy is administered by slow IV drip, over a period of 1 – 4 hours each time. IV therapy allows NAD+ / NMN+ to go directly to the brain, where it binds with opioid receptors. During treatment, the patient may use a hand phone, read a good book, or most preferably, we encourage sleep and rest. The body only heals during deep sleep and rest.
Advanced NAD+ NMN+ IV Therapy, with optional natural nutrients treatment at BSI, produces beneficial precursors and balances hormones… We want to heal the body, make it better utilize and produce native NAD and all related functions for the long term.
After the initial series of treatments, many patients return for occasional maintenance boosters.
Please note that for dosages of 150 mg or more, we request of the patient full blood and urine testing in order to determine reasons as well as proper prescription for NAD+ IV Therapy. We must determine if the body is well able to benefit and tolerate intensive NAD+ IV therapy.
Please see information here about The BSI 43 Day Detox, with 133 Lab Tests and Comprehensive Analysis. NAD+ NMN+ IV therapy can be received concurrently with the Detox, making for the best possible outcome in the shortest time. Or you may also request testing without detox.
There are numerous therapeutic benefits from intravenous NAD+ therapy for anti-aging, with emphasis on NMN+ taken concurrently. Native NAD declines with age and thus hinders natural repair mechanisms within cells. Raising intracellular NAD levels with NAD+ and NMN+ IV Therapy is a powerful therapeutic strategy for age-associated degenerative diseases in general and to extend lifespan.
NAD+ NMN+ Augments Anti-Aging Therapies Because….
Suggested additions to IV therapy include: B Complex, Glutathione, Collagen magnesium, ALA, Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as AGE, NBH, ADP, IMF, BON and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV therapy can greatly improve arterial function – blood vessels dilate more effectively and arteries became less stiff.
A course of therapy with larger emphasis on NMN+, and including occasional EDTA Chelation Therapy, works by reducing oxidative stress while boosting protective molecules like elastin in the blood vessels. What’s more, it can help to restore SIRT1 activity, an important enzyme for vascular health, while decreasing harmful oxidative byproducts in the arteries.
NAD+ NMN+ EDTA IV therapy, has shown in clinical studies to enhance cardiovascular health. By boosting NAD levels, these therapies can improve blood flow, support heart function, and enhance overall metabolic health, potentially reducing the risk of heart disease and promoting a healthier, more active lifestyle, when also combined with EDTA Chelation Therapy.
Benefits of NAD+ and NMN IV Therapy for Cardiovascular Health….
Suggested additions to IV therapy include: the addition of Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as BDB, BDC, CRD, TRI, AGE, NBH, ADP, IMF, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV therapy, with larger emphasis on NAD+, is especially helpful for those addicted to alcohol, nicotine, and opioid drugs and other similar addictions. It binds to opioid receptors and reduces the symptoms of withdrawal. It causes the body to replace the vitamins and minerals which have been depleted from substance excesses.
Benefits of NAD+ NMN+ IV Therapy as part of a holistic recovery strategy include…
Dealing with addiction is rarely easy, whether it be something simple such as sugar (refined white sugar is processed the same way as heroin, and is actually more addictive), or more complicated such as alcohol (alcohol is the most refined form of sugar, hits the brain in 6 seconds). Opiates can be a little easier though, if protocol is followed, and the patient has willingness to proceed.
It is often recommended that NAD+ NMN+ IV Therapy be combined with addiction counseling and / or participation in a recovery program such as a 12-step group. Sometimes psychotherapy is needed to deal with issues such as mental illness, family dysfunction or PTSD. However, with the help of NAD+ and NMN+, you can more effectively and easily stop using the toxic substance(s) and deal with related issues. BSI does not provide psychotherapy at this time, however limited counseling is included.
Suggested additions to IV therapy include: the addition of Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as NBH, ADP, SAA, SAN, SAO, SSV, ANX, DPN and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
Research has validated that NAD+ NMN+ Therapy restores neurovascular coupling responses to youthful levels while improving spatial memory and movement coordination.
The cognitive improvements stem from reduced oxidative stress and better blood vessel function in the brain, with the study pointing to NMN+ in restoring native NAD levels and mitochondrial function.
IV Therapy, with emphasis on NAD+ with optional natural nutrients treatment, is beneficial to counter effects of aging, chronic depression and brain dysfunction. Naturally occurring levels of native NAD decrease as the body ages. NAD+ NMN+ IV Therapy counters many of the effects of aging which are caused by NAD depletion over time.
Benefits of NAD+ NMN+ IV Therapy as part of a holistic recovery strategy include…
Brain and nervous system improvements are gained…
NAD+ NMN+ EDTA Treatment is especially helpful for those seeking treatment as part of a holistic recovery strategy include…
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as ANX, DPN NBH, ADP, STK, NRV, NST, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ and NMN+ IV therapy can be beneficial in chronic disease healing or recovery, by enhancing energy production, supporting DNA repair, and improving overall cellular health. These cutting edge therapies help in managing metabolic disorders and improving insulin sensitivity, which can be crucial for overall health. Supports recovery from various chronic diseases by replenishing NAD+ levels, essential for cellular function.
NAD+ NMN+ Can Help to Heal Many Chronic Diseases….
Improvement and healing are derived from….
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha Lipoic Acid), Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as ADP, IMN, NBH, SIP, ENG and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV therapy has shown promising results in the context of COVID-19 recovery. This innovative treatment works by restoring cellular energy levels, which can often be depleted following illness or injury. Many individuals recovering from COVID-19 experience lingering symptoms such as fatigue and brain fog—commonly referred to as Long COVID.
Research and experience indicates that native NAD levels deplete during COVID-19, affecting cellular energy and immune function. This cutting edge therapy has been reported to significantly reduce recovery time for post-COVID symptoms like fatigue and brain fog, improving cognitive function and overall vitality. In some cases, recovery time has been reduced from 2-3 months to just a few days with the administration of NAD+ NMN+ and related therapies.
By directly delivering NAD+ into the bloodstream, this therapy not only boosts energy but also helps reduce inflammation throughout the body. This dual action can significantly alleviate the debilitating symptoms and enhance overall vitality, aiding in a more effective recovery process. And combined with EDTA chelation IV, pathogens related to injections can begin to be eliminated, and damaged DNA repaired.
Benefits of NAD+ NMN+ EDTA Therapies for COVID 19 injuries….
Benefits for healing DNA damage
NAD+ and NMN IV therapy can significantly aid in healing COVID-19 injuries by restoring energy levels, repairing cellular damage, and supporting immune function. This therapy is particularly beneficial for those experiencing lingering effects after recovering from the virus.
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compound IN, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Zinc, Vitamin C or Vitamin D injection. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as SIP, ABO, ADP, DPN, ANX, IMN, NBH, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV infusion therapy offers a comprehensive approach to improving skin health, targeting the underlying cellular processes that affect aging and skin vitality.
By rejuvenating skin cells, promoting collagen production, and reducing inflammation, this therapy holds great promise for those seeking to restore their skin’s youthful appearance.
A study published in Glycative Stress Research shows that NAD+ NMN+ supplementation significantly improves multiple aspects of skin health over 8 weeks, including moisture, firmness, and roughness. The study documented meaningful reductions in skin autofluorescence values, indicating lower levels of advanced glycation end products (AGEs) in skin. Patients experienced visible improvements in their skin’s appearance, with measurable changes in age spots, wrinkles, and freckles.
Documented benefits of NAD+ NMN+ Therapy for skin improvement….
NAD+ (β-Nicotinamide Adenine Dinucleotide) and NMN+ (β-Nicotinamide Mononucleotide) are vital coenzymes that play crucial roles in cellular function, particularly in energy metabolism and DNA repair. Their infusion therapy can lead to significant improvements in skin health through several key mechanisms:
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as AGE, SIP, ABO, ADP, DPN, ANX, IMN, NBH, SPQ, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV therapy collectively supports enhanced metabolic health, improved insulin sensitivity, and helps manage diabetes and insulin resistance, promoting a more efficient metabolic state within the body.
Native NAD is a vital cellular coenzyme that powers mitochondrial energy production and activates repair enzymes called sirtuins. NMN+ is a direct precursor your cells convert into NAD. When given by IV, NAD+ NMN+ rapidly raises blood and tissue NAD levels, restoring mitochondrial function, boosting cellular energy, gradually stimulating the body to produce NAD, and lowering oxidative stress.
Increased NAD activates sirtuins and other pathways that improve insulin signaling, reduce inflammation, enhance fat oxidation, and protect pancreatic beta cells—together easing insulin resistance and helping restore metabolic and glucose control.
Benefits of NAD+ and NMN IV therapy for Metabolic Health, Diabetes, Insulin Resistance Recovery
How Therapy can help metabolic health, diabetes, and insulin resistance….
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as WGT, MBS, ENG, SIP, ABO, ADP, IMN, NBH, SPQ, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ (and its precursor NMN+) help repair DNA damage mainly by enabling enzymes that detect and fix damaged DNA and by supplying cellular energy needed for repair.
A review article by Rahman et al. published in Aging and Disease discusses how therapy with emphasized NMN+ reduces DNA damage and cellular aging in human cells.
The compound works by raising NAD+ levels and activating PARP1 (poly ADP-ribose polymerases) , which helps repair damaged DNA strands. These findings point to NMN+ as a treatment for preventing and reversing age-related DNA deterioration.
Both NMN+ and NAD+ therapies can support DNA repair, essential for cellular health. NAD+ therapy excels in this aspect as it directly activates important enzymes involved in DNA repair processes, helping mitigate the effects of oxidative damage from aging and diseases, including those induced by viral infections.
How does NAD+ NMN+ Therapy work in repair of damaged DNA?
NAD+ is a vital cellular coenzyme that powers mitochondrial energy production and activates repair enzymes called sirtuins. NMN+ is a direct precursor your cells convert into NAD+. When given by IV, NAD+ NMN+ rapidly raises blood and tissue NAD+ levels, restoring mitochondrial function, boosting cellular energy, and lowering oxidative stress.
Increased NAD+ activates sirtuins and other pathways that improve insulin signaling, reduce inflammation, enhance fat oxidation, and protect pancreatic beta cells—together easing insulin resistance and helping restore metabolic and glucose control.
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as SAA, SAN, SAP, SSV, SIP, WGT, MBS, ABO, ADP, IMN, NBH, SPQ, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ and its precursor NMN+ when given by IV Infusion Therapy, helps the eye by quickly boosting the energy supply inside retinal cells so they can function and survive, activating repair proteins that fix damaged cell parts and DNA, and lowering harmful oxidative stress and inflammation that would otherwise damage photoreceptors and support cells.
It also supports tiny blood vessels and waste clearing cells in the retina, which together can slow degeneration and help preserve vision.
A 2023 review examined NMN’s role in treating eye diseases, drawing from recent literature and original research. Studies demonstrated that NMN helped regulate inflammation, oxidative stress, and metabolism in conditions like glaucoma, retinopathy, and macular degeneration.
Combined with Therapure Nutraceuticals Compound ED Eye Drops, healing becomes more effective.
How does NAD+ NMN+ IV Therapy work to heal eye function?
How does this help heal eyes?
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as VSN, ED, SIP, DBT, MBS, ABO, ADP, IMN, NBH, SPQ, and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ MNM+ IV Therapy, With Optional Natural Nutrients, for Increased Energy and Stamina.
BSI experience and medical research shows NAD+ NMN+ supplementation helps restore native NAD levels, which supports healthy energy metabolism and mitochondrial function. This increased NAD+ availability allows for better cellular energy production and improved metabolic efficiency. NMN+ supplementation may also optimize sirtuin proteins’ ability to regulate energy at the cellular level through its effects on NAD+.
Human body cell mitochondria are often referred to as the “powerhouses” of the cell, generate adenosine triphosphate or ATP, the molecule that provides energy for cellular processes. ATP is produced through oxidative phosphorylation, which takes place in the mitochondria. This process relies on the presence of nicotinamide adenine dinucleotide (NAD). Native NAD decreases with age.
In a simpler equation: More NAD = more ATP = more cellular energy = you’ll feel increased energy in your daily activities.
How does NAD+ NMN+ IV Therapy work to Boost Energy and Stamina and Muscle Endurance?
NAD+ IV Therapy: Provides immediate energy boosts, aiding in recovery and performance during intense physical activities.
NMN+ IV Therapy: Can improve muscle endurance and energy metabolism, beneficial for athletes looking to enhance performance.
Together they….
Yes. NAD+ NMN+ IV therapy can help boost energy, stamina, and muscle endurance by….
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as AGE, ENG, SIP, BDB, BDC, ABO, ADP, IMN, MBS, NBH and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
NAD+ NMN+ IV Therapy With Optional Natural Nutrients for Weight Loss.
NAD+ NMN+ IV therapy with optional natural nutrients treatment is especially helpful as part of an holistic weight loss treatment. Native NAD plays a vital role in metabolism by helping convert nutrients into energy the body can use. It does this by acting as a co-factor for several enzymes, that serve to metabolize carbohydrates, fats, and proteins.
Intravenous administration of high-dose NAD+ NMN+ IV Therapy has emerged as a potent therapy for weight management. Extensive research indicates this therapy enhances mitochondrial function, leading to increased energy expenditure and improved metabolism.
How does this work?
NAD+ is a key helper molecule inside cells that keeps energy systems running. When IV NAD+NMN+ raises NAD levels, it turns on proteins (like sirtuins) that tell cells to make more and better mitochondria, the parts that burn fuel for energy. That raises your resting calorie burn and shifts the body to use more fat for fuel instead of storing it. It also improves insulin response and lowers inflammation, so your body is less likely to pack on fat.
These changes can make it easier to lose weight and keep it off long term, but they don’t replace healthy eating and regular activity. Strong, lasting weight loss still depends on maintaining proper food combining, limited carbohydrate intake and lifestyle changes.
Over time, these molecular shifts can make the body more metabolically efficient and less prone to regain weight, but they do not rewrite behavioral drivers of energy balance; durable, “permanent” weight loss still requires persistent caloric balance and lifestyle changes.
What NAD+ NMN+ Therapy can do….
Suggested additions to IV therapy include: Vitamin B Complex, Glutathione, Collagen Magnesium, ALA (Alpha lipoic acid), Homeopathic Compounds IN and IZ, Condroitin Sulfate, L-Carnatine, Lysine, NAC, Piracetam, Vitamin C. However rarely more than one or two should be added with each IV in order to minimalize Herxing effects.
Also consider the addition of one or more Therapure Nutraceuticals Oral Compounds, such as WGT, MBS, AGE, ENG, SIP, BDB, BDC, ABO, ADP, IMN, NBH and others as determined through pre-therapy interview and optional testing.
Lifestyle and dietary changes may also be suggested.
We like to combine them in varying ratios depending on your goals....
It’s really important to clearly distinguish between Native NAD (NAD) and Native NMN (NMN), against beta NAD (NAD+) and beta NMM (NMN+).
Native NAD (nicotinamide adenine nucleotide) refers to a critical coenzyme found in every cell in the body, and it’s involved in hundreds of metabolic processes. NAD contains nicotinamide ribose and nicotinamide adenine nucleotide bound to nicotinamide ribose through a phosphodiester bond. It’s naturally produced in the body.
Native NMN (nicotinamide mononucleotide) refers to a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine. NMN contains nicotinamide, ribose, and a phosphate group. It’s naturally produced in the body.
Native NAD levels in the body decrease with the age, but increasing native NAD with NAD+ NMN+, many ailments can improve or be healed.
NAD+ (β-Nicotinamide Adenine Dinucleotide), is a supplemental and medicinal derivative of Niacin (Vitamin B3). NAD, NAD+, NMN+, and Niacin are unrelated to nicotine.
NMN+ (β-nicotinamide mononucleotide), is the precursor of native NAD, a naturally-occurring form of all living organisms. It contains nicotinamide, ribose, and a phosphate group. Therefore, it is an RNA nucleotide. As such, this may help to repair damages from mRNA exposures.
More specifically….
NAD+ IV Therapy: Gives a rapid initial increase in intracellular NAD+ levels, but the decay is more pronounced after the treatment period ends, leading to a faster drop-off in native NAD levels. This is valuable when rapid increase is needed, more so at the beginning of therapy.
NMN+ IV Therapy: Exhibits a slower, more gradual increase in NAD saturation, which is sustained over time. Even after stopping the treatment, the decay is slower, providing a more prolonged elevation in NAD levels. However the body will also be stimulated, over time with added multiple IVs, to begin to produce NAD internally, at more youthful levels.
By Dr. Jo, Chief Scientist and Head Doctor with BSI International Clinics at Bali.
NAD+ IV (red): Shows a rapid initial increase in intracellular NAD+ levels, but the decay is more pronounced after the treatment period ends on Day 7, leading to a faster drop-off in NAD+ levels. This is valuable when rapid increase is needed, more so at the beginning of therapy.
NMN+ IV (blue): Exhibits a slower, more gradual increase in NAD+ saturation, which is sustained over time. Even after stopping the treatment at around at day 7, the decay is slower, providing a more prolonged elevation in NAD+ levels. However the body will also be stimulated, over time with added multiple IVs, to begin to produce NAD internally, at more youthful levels.
Native NAD (green): Normal levels at 25 years of age.
Native NAD (olive green): Normal decreased levels at 65 years of age.
Body-produced (native) NAD often remains elevated for some time after repeated NMN+ IV infusions but gradually returns toward baseline over weeks; it typically does not stay permanently high without continued dosing or supportive lifestyle changes.
Typical pattern observed in preclinical and early human studies: Native NAD levels fall gradually over days–weeks (often measurable for several weeks) rather than immediately returning to baseline. The longer and higher the dosing course, the longer the persistence.
Long term maintenance: Without ongoing NAD+, or preferably NMN+, or interventions that support NAD biosynthesis (exercise, calorie restriction/fasting patterns, adequate niacin precursors, sleep, reduced inflammation), native NAD normally drifts back down to near pre treatment set points over months.
By Dr. Jo, Chief Scientist and Head Doctor with BSI International Clinics at Bali.
Combined therapy benefits varies depending on the specific health aspects you’re targeting and your individual biology. Research and user experiences suggest different time frames for various effects:
Immediate Energy Effects (Hours to Days): Some users report feeling increased energy and mental clarity within the first few hours of therapy, as NAD+ NMN+ begin supporting cellular native NAD production.
Short-Term Benefits (2-4 Weeks): Improvements in physical performance, exercise capacity, and energy metabolism typically become noticeable within the first month of consistent therapy.
Mid-Term Changes (1-3 Months): Skin health improvements, better sleep quality, and cognitive function benefits often become apparent during this period, as demonstrated in several clinical studies.
Long-Term Benefits (3-6 Months+): More fundamental improvements in cardiovascular health, metabolic function, and age-related markers typically require several months of consistent therapy to become noticeable.
Preventive Benefits (Ongoing): Most of the important effects, such as DNA repair and longevity support, work continuously in the background and may not have immediately noticeable effects but contribute to long-term health maintenance.
Both NAD+ (β-nicotinamide adenine dinucleotide) and NMN+ (β-nicotinamide mononucleotide) therapies aim to boost cellular health and combat aging. However, they differ significantly in their effectiveness and delivery methods.
Key Differences
Absorption and Bio-availability
Short-term vs Long-term
NMN+ IV Therapy: Offers quick energy boosts and supports long-term cellular health, making it suitable for ongoing wellness.
NAD+ IV Therapy: Provides immediate effects on energy levels, but may require repeated sessions for sustained benefits.
In essence, while both NAD+ and NMN+ therapies provide significant health benefits, NAD+ IV therapy primarily stands out for its robust applications in weight loss, recovery from COVID-19 and DNA damage repair. NMN+ therapy may be more effective for boosting energy levels and supporting longevity. BSI can help determine the best approach based on specific health goals. Combined, both short term and long term benefits and healing are greatly amplified.
A rare side effect of NAD+ NMN+ IV therapy is muscle tension or ache (if the IV is taken too fast – and the patient is dehydrated). Muscles in the stomach, back, shoulders, legs, and arms can feel sore as if you just did some heavy lifting at a gym. BSI Therapure Nutraceuticals can provide herbal medicines that can help. Mild stretching, heating pads, and essential oils are another remedy to explore.
Imagine a mild wave of pressure rolling over your entire body. For someone who is new to receiving NAD+ NMN+ IV Therapy, the wave can be less than comfortable, but don’t let this deter you from receiving the treatment. The wave lasts for a few brief moments before it subsides.
Patients who decide to push their luck and try to cut down their infusion time by increasing the drip rate will experience a rush. Rapid heart rate, headache, and a jolt of energy followed by a wave of pressure, that can be a very unpleasant feeling. Don’t do this.
It is important to remember that NAD+ NMN+ needs to be administered at a slow rate for health benefits. The more obvious reason is to reduce any discomfort one may experience with a rush of NAD+ NMN+ , but more importantly, NAD+ NMN+ is more readily absorbed into the cells at a slower rate. In other words, a slow drip will have more therapeutic benefit.
If the IV is taken too fast, strong, temporary headache can result.
While not everyone has an emotional experience or breakthrough when receiving the therapy, it is still a good idea to have a box of tissues on hand. Congested sinuses and a runny nose often result from the NAD+ NMN+ therapy. Holistic therapy includes all aspects of the patient’s healing, including emotional, spiritual, physical, mental. Any reactions are usually related to the detox that comes with this therapy.
An increase in appetite can be a hit or miss for most individuals. Some people enjoy snacking during the treatment, whereas some people prefer to fast for the day. Either way, we recommend bringing some healthy, non-sugar snacks (fresh fruit is okay) just in case. Headache or other reactions are less likely too occur if blood glucose is balanced. Addictions are often directly related to sugar consumption.
Proper diet is also of great concern. If consuming addictive foods, such as sugar-filled refined foods, healing will be much more difficult. We recommend a simple diet of whole foods during therapy. So, when combined with a whole foods diet, proper nutrients needed for rebuilding and cleansing of body tissues are provided, addictions are then truly healed. NAD+ NMN+ requires proper nutrients, not junk food, to stabilize hormones and the endocrine system.
These effects tend to be more prominent in first time users, or with those who take too-large doses. Experienced users tend to not experience ‘inconvenient reactions’ but rather enjoy the benefits of NAD+ Therapy within hours of administration. No inconvenient reactions would indicate a larger dose could be taken at a later date.
Within 1-4 hours after completion of NAD+ IV Therapy
In the event of detox, the patient may on rare occasion experience low-grade fever, digestive distress, or dull headache or general aching. Remember that the body bakes out pathogens with heat, and these both indicate the therapy is working – body language, your body is telling you therapy is working.
Evening after NAD+ IV Therapy
On rare occasion, the patient may experience cold sweats during sleep, which indicates the body is eliminating toxins that were liberated from skin layers and the circulatory system. This is a very good Herxing reaction, meaning immunities are strong and the body is healing. We are stimulating your body to heal herself, a methodology that is fully suppressed in modern medicine that instead mandates suppression rather than healing.
In other cases, the patient may simply begin to quickly experience myriad benefits of NAD+ therapy.
Next day after completion of NAD+ IV Therapy
Patients may find they need to sleep a little more during the following 24-36 hours. The body only heals during deep sleep and rest. The patient may experience increased urination or other eliminations.
Second day after completion of NAD+ IV Therapy
Patients usually begin to fully experience the benefits of NAD+ therapy by now, which mainly include increased cognition and energy, skin improvement, better muscle tone and excess weight decrease, and a decrease in cravings or addictions.
Something that we see people misunderstanding more than often.
You may have seen blogs or social media posts suggesting that NAD+ NMN+ IV therapy is a quick fix for energy, anti-aging, or mental clarity. Unfortunately, this is oversimplified. While some people feel better after one session, the true benefits come with consistency over time.
Let’s break it down scientifically and practically. Here are some key points to keep in mind:
a. NAD+ is not stored in cells for long. It only lasts hours or a few days, depending on the tissue. It’s constantly used in important processes like:
After a single IV infusion, NAD levels go up, but they go back down within days. This is because cells use NAD up quickly, and stressors like aging, inflammation, poor sleep, toxins, and metabolic disorders can deplete NAD levels even faster. So, you need to keep replenishing NAD (with NAD+ and / or NMN+) to keep improving.
b. Native NAD Levels Decline Over Time
c. Mitochondrial Remodeling Takes Time
a. Sensationalism vs. Science
b. Lack of Emphasis on Individualization
- Blood markers improve (CRP, hs-CRP, homocysteine).
- Oxidative stress markers decrease.
- Muscle recovery time improves.
- Subjective improvements include less fatigue, better sleep quality, and improved mental sharpness.
- Mitochondrial efficiency increases (ATP production capacity).
- VO2 max (fitness testing) increases.
- DNA damage markers decrease (8-OHdG).
- Glucose tolerance improves (HbA1c decreases).
- Measurable gains in endurance occur.
- Faster recovery from exercise happens.
- Oxidative damage decreases.
- The DNA methylation clock decreases by 1-3 years.
- Mitochondrial density increases (muscle biopsies or advanced testing).
- Insulin sensitivity increases.
- Systemic inflammation decreases (IL-6, TNF- ).
- Cellular resilience increases.
- The disease risk trajectory decreases.
- Longevity pathways are fully active.
(A Three Months Plan)
