Howell-Jolly Body

Howell-Jolly Bodies most commonly arise when spleen is absent or spleen function is impaired (hyposplenia). Occasional Howell Jolly bodies may arise in physiological conditions.

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Hypo’splenism: Physiological

  • Causes including normal individuals (very infrequent), pregnancy (infrequent), neonates (frequent) – more common in hyposplenic states
 

Hyposplenism: Pathological absence

  • Congenital asplenism
 

Hyposplenism: Pathological hypofunction Including:

  • Normal neonates, Celiac Disease, Bone marrow transplant, Pregnancy
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