Irregularly Contracted Cell

Implies damage to hemoglobin within the red cell often accompanied by cellular dehydration and membrane damage; acute oxidative damage to red cells should be considered.

https://haematologyetc.co.uk/index.php?title=Irregularly_contracted_cells

Abnormal hemoglobin forms (look for associated typical cell forms)

  • Sickle cell disease (including variant forms)
  • Hemoglobin C disease
  • Unstable haemoglobin
  • Thalassemias
 

Pathological causes

  • Infiltrated bone marrow: (look also for white cell precursor cells): consider leukemia, myelofibrosis or infiltrating solid tumor.
 

Conditions associated with erythroid expansion

  • Hemoglobinopathy (particularly thalassemia); severe membrane disorder with hemolysis; dyserythropoietic anemias
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