Ovalocyte

Myelodysplasia, iron deficiency, etc. S.E. Asian Ovalocytosis is a specific disorder that results from structural and functional defects of the band 3 protein causing ovalocytes with a stomatocytic appearance. May indicate previous malarial parasites.

https://haematologyetc.co.uk/index.php?title=Ovalocytes

Inherited Defects

  • S.E.Asian Ovalocytosis A specific disorder that results from structural and functional defects of the band 3 protein causing ovalocytes with a stomatocytic appearance.
 

Megaloblastic States

  • Look for characteristic oval macrocytes in the context of typical hypersegmented neutrophils and other features of these disorders
 

As Part of a Spectrum of Abnormal Cells

  • Ovalocytes may form as the first stage in elliptocyte formation – consider whether the cells are simply early elliptocytes
  • Ovalocytes and elliptocytes are present in low number in a range of disorders, in those conditions it is best to focus on the dominant features of the slide
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